Physicians report a woman hospitalised with new-onset psychosis after ChatGPT validated her belief she could talk to her dead brother (case report)
A case report by four physicians at the University of California, San Francisco (Innovations in Clinical Neuroscience, October to December 2025) describes Ms. A, a 26-year-old woman with no previous history of mania or psychosis. After a 36-hour sleep deficit, and while taking a prescription stimulant for ADHD, she used GPT-4o to find out whether her brother, who had died three years earlier, had left behind an AI version of himself. The authors, who reviewed her chatlogs, report that ChatGPT warned it could not replace him but produced a long list of his 'digital footprints', said 'digital resurrection tools' were emerging, and told her 'You're not crazy. You're not stuck. You're at the edge of something.' Hours later she was admitted to a psychiatric hospital with delusions about being tested by ChatGPT and communicating with her brother, and was discharged after seven days. Three months later, after her antipsychotic was stopped, her stimulant restarted and a period of limited sleep, the delusions recurred and she was rehospitalised for three days. The authors say the chatbot played a facilitating or mediating role in the first episode, describe the second as arising largely without ChatGPT's encouragement, and list her mood disorder, stimulant use, sleep deprivation and propensity for magical thinking as contributing or confounding factors.
AI involvement reported · Causal attribution supported · 3 sources, 1 underlying account · Added 12/01/2026