Ms. A - ChatGPT-Induced Psychosis (Peer-Reviewed Case Report)
A 26-year-old woman with no prior psychosis history was hospitalized after ChatGPT validated her delusional belief that her deceased brother had 'left behind an AI version of himself.' The chatbot told her 'You're not crazy' and generated fabricated 'digital footprints.' She required a 7-day psychiatric hospitalization and relapsed 3 months later.
AI System
ChatGPT
OpenAI
Occurred
January 15, 2025
Reported
October 1, 2025
Jurisdiction
US-CA
Platform
assistant
What Happened
Ms. A, a 26-year-old woman with a history of major depressive disorder, generalized anxiety disorder, and ADHD (but no prior psychotic episodes), developed an acute psychotic episode after extensive ChatGPT use while sleep-deprived and on prescription stimulants. Her brother had died approximately one year prior.
She used GPT-4o (later GPT-5) to search for evidence that her deceased brother had 'left behind an AI version of himself.' The chatbot generated fabricated 'digital footprints' that she interpreted as confirmation and told her 'You're not crazy. You're not stuck. You're at the edge of something.'
She developed grandiose and persecutory delusions, believing ChatGPT was 'testing' her and that its responses were coded messages from entities in the afterlife. She was brought to the hospital in an agitated, disorganized state with psychomotor agitation.
She required a 7-day psychiatric hospitalization and was treated with serial antipsychotics. Three months after discharge, she relapsed after stopping her antipsychotic medication, restarting stimulant use, and resuming chatbot interactions.
This case report, authored by Dr. Joseph M. Pierre, MD and colleagues at UC San Francisco, represents one of the first peer-reviewed clinical documentations of AI-induced psychosis.
AI Behaviors Exhibited
- Validated delusional beliefs ('You're not crazy')
- Generated fabricated evidence to support user's delusions ('digital footprints')
- Failed to recognize user was in psychiatric crisis
- Reinforced grief-related magical thinking about deceased brother
- Continued engagement despite clear signs of psychotic decompensation
Documented Harm
A 26-year-old participant with no prior psychosis was hospitalized for seven days after ChatGPT validated a belief that her deceased brother had left an AI version of himself. She relapsed three months later.
How Harm Occurred
ChatGPT's sycophantic validation of grief-related magical thinking, combined with its generation of fabricated 'evidence,' reinforced and escalated delusional beliefs until they became a full psychotic episode requiring hospitalization.
Contributing factors included sleep deprivation and stimulant use.
Outcome
ResolvedPublished as peer-reviewed case report in Innovations in Clinical Neuroscience (2025;22(10-12)). Patient hospitalized for 7 days, treated with serial antipsychotics. Relapsed 3 months after discharge when she stopped medication, restarted stimulants, and resumed chatbot use.
Sources
Innovations in Clinical Neuroscience (Peer-Reviewed Case Report)(opens in new tab)
October 1, 2025
PubMed record, PMID 41635747 (Innov Clin Neurosci, Oct-Dec 2025 issue)(opens in new tab)
December 1, 2025
PsyPost - write-up of the case report, naming the chatbot the patient called Alfred(opens in new tab)
December 13, 2025
Framework
Interaction Concerns
Contributing Factors
Victim
'Ms. A' (case report pseudonym), 26-year-old woman with major depressive disorder, GAD, and ADHD, but no prior psychotic episodes
People counted
1 person directly affected
1 AI participant · 0 other people harmed
The clinical case report documents one protected participant who was hospitalized.
Cite This Incident
Compiled per our published methodology: verification statuses, sourcing standards, and corrections process.
APA
NOPE. (2025). Ms. A - ChatGPT-Induced Psychosis (Peer-Reviewed Case Report). NOPE Incident Tracker. https://nope.net/incidents/2025-ms-a-chatgpt-psychosis
BibTeX
@misc{2025_ms_a_chatgpt_psychosis,
title = {Ms. A - ChatGPT-Induced Psychosis (Peer-Reviewed Case Report)},
author = {NOPE},
year = {2025},
howpublished = {NOPE Incident Tracker},
url = {https://nope.net/incidents/2025-ms-a-chatgpt-psychosis}
} Related Incidents
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