Case report: man self-treated with colchicine after a DeepSeek dialogue pointed to a rare fever syndrome; liver enzymes rose before specialist review
Clinicians at the University Medical Center Hamburg-Eppendorf report in EULAR Rheumatology Open (published 29 September 2026) a man in his thirties with nearly three decades of unexplained febrile attacks who, in a dialogue with DeepSeek begun on 28 June 2025, saw the model's differential narrow to familial Mediterranean fever (FMF). The authors write that the model repeatedly recommended specialist assessment but also discussed a diagnostic trial of colchicine with specific dosing. Motivated by the hypothesis, he arranged commercial genetic testing and obtained colchicine from a pharmacy in Egypt, starting it without specialist supervision. His attacks stopped, but his alanine aminotransferase rose to 160 U/L and colchicine was paused and later resumed at a lower dose. FMF was confirmed when he presented to the clinic in February 2026. The authors write that the case illustrates how patient-facing models may facilitate recognition of rare autoinflammatory diseases, and that confident diagnostic language combined with actionable treatment advice may also encourage unsupervised testing and self-medication.
AI involvement reported · Causal attribution alleged · 1 source · Added 12/10/2026